Reaction: THCA is conjugated with Coenzyme A (SLC27A5 BACS)
THCA (25(R) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate) , coenzyme A, and ATP react to form the CoA conjugate of 25(R) THCA, AMP, and pyrophosphate. This cytosolic reaction is catalyzed by SLC27A5 (BACS). SLC27A2 (VLCS) also catalyzes this reaction; the relative contributions of the two enzymes to de novo bile acid synthesis in vivo are not certain (Mihalik et al. 2002).
Reaction - small molecule participants:
PPi [cytosol]
25(R) THCA-CoA [cytosol]
AMP [cytosol]
THCA [cytosol]
ATP [cytosol]
CoA-SH [cytosol]
Reactome.org reaction link: R-HSA-192137
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Reaction input - small molecules:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oic acid
ATP(4-)
coenzyme A(4-)
Reaction output - small molecules:
diphosphate(3-)
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-192137