Meta-Biol : Reactions : 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA

Reaction: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA

- in pathway: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to form (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA. This reaction, catalyzed by the peroxisomal D-bifunctional enzyme (Huyghe et al. 2006), occurs in the peroxisomal matrix.

Reaction - small molecule participants:

(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA [peroxisomal matrix]

H2O [peroxisomal matrix]

THCA-CoA [peroxisomal matrix]

Reactome.org reaction link: R-HSA-192331

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Reaction input - small molecules:

water

ChEBI:15377

3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA

ChEBI:27505

Reaction output - small molecules:

(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA

ChEBI:52050

Reactome.org link: R-HSA-192331