Reaction: Oxidation of cholesterol to 22beta-hydroxycholesterol
- in pathway: Pregnenolone biosynthesis
Cholesterol and NADPH + H+ react to form 22beta-hydroxycholesterol, NADP+, and H2O, catalyzed by CYP11A (P450scc) associated with the inner mitochondrial membrane.
Reaction - small molecule participants:
NADP+ [mitochondrial matrix]
22b-HCHOL [mitochondrial inner membrane]
H2O [mitochondrial matrix]
O2 [mitochondrial matrix]
H+ [mitochondrial matrix]
CHOL [mitochondrial inner membrane]
NADPH [mitochondrial matrix]
Reactome.org reaction link: R-HSA-193054
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Reaction input - small molecules:
dioxygen
hydron
cholesterol
NADPH
Reaction output - small molecules:
NADP(+)
(22S)-22-hydroxycholesterol
water
Reactome.org link: R-HSA-193054