Reaction: Hydrolysis of choloyl-CoA to cholate and CoASH
The peroxisomal matrix enzyme acyl-coenzyme A thioesterase 8 (ACOT8) mediates the hydrolysis of choloyl-CoA to form cholate and CoASH (Jones et al. 1999, Hunt et al. 2002). While bile salts are the major product of the de novo biosynthetic pathway in the normal human liver, bile acids are major feedback regulators of this pathway and this hydrolysis reaction is thought to play a role in generating them (Russell 2003).
Reaction - small molecule participants:
cholate [peroxisomal matrix]
CoA-SH [peroxisomal matrix]
H2O [peroxisomal matrix]
choloyl-CoA [peroxisomal matrix]
Reactome.org reaction link: R-HSA-193385
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Reaction input - small molecules:
water
choloyl-CoA(4-)
Reaction output - small molecules:
cholate
coenzyme A(4-)
Reactome.org link: R-HSA-193385