Reaction: 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA)
3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al, NADPH + H+, and O2 react to form 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA), NADP+ and H2O. This oxidation reaction occurs in the mitochondrial matrix, catalyzed by CYP27A1.
Reaction - small molecule participants:
NADP+ [mitochondrial matrix]
DHCA [mitochondrial matrix]
H2O [mitochondrial matrix]
O2 [mitochondrial matrix]
3alpha,7alpha-dihydroxy-5beta-cholestan-26-al [mitochondrial matrix]
H+ [mitochondrial matrix]
NADPH [mitochondrial matrix]
Reactome.org reaction link: R-HSA-193460
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Reaction input - small molecules:
dioxygen
3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
hydron
NADPH
Reaction output - small molecules:
NADP(+)
3alpha,7alpha-dihydroxy-5beta-cholestan-26-oic acid
water
Reactome.org link: R-HSA-193460