Reaction: (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA
(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA and NAD+ react to form 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, NADH, and H+. This oxidation reaction, catalyzed by the peroxisomal D-bifunctional enzyme (Huyghe et al. 2006), occurs in the peroxisomal matrix.
Reaction - small molecule participants:
H+ [peroxisomal matrix]
3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA [peroxisomal matrix]
NADH [peroxisomal matrix]
3,7,24THCA-CoA [peroxisomal matrix]
NAD+ [peroxisomal matrix]
Reactome.org reaction link: R-HSA-193508
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Reaction input - small molecules:
3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA
NAD(1-)
Reaction output - small molecules:
hydron
3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA
NADH(2-)
Reactome.org link: R-HSA-193508