Reaction: Sphingomyelinase is activated by the NGF:p75NTR complex
- in pathway: Ceramide signalling
NGF binding to p75NTR activates N-SMase (Neutral sphingomyelinase), and possibly A-SMase (acid sphingomyelinase), an enzyme that converts sphingomyelin to ceramide. The mode and mechanism of interaction between p75 and N-SMase have not been determined but is thought to involve the recruitment of Mg2+ to the active site of the enzyme.
Reaction - small molecule participants:
Mg2+ [plasma membrane]
Reactome.org reaction link: R-HSA-193672
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Reaction input - small molecules:
magnesium(2+)
Reaction output - small molecules:
Reactome.org link: R-HSA-193672