Reaction: Production of ceramide which can activate JNK and other targets
- in pathway: Ceramide signalling
Sphingomyielinase promotes the conversion of sphingomyelin to ceramide. Ceramide can activate JNK and other targets. The molecular details of the p75NTR-activated ceramide signalling cascade are only partially understood.
Reaction - small molecule participants:
CERA [cytosol]
ChoP [cytosol]
SPHM [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-193706
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Reaction input - small molecules:
sphingomyelin d18:1
water
Reaction output - small molecules:
N-acylsphingoid
phosphocholine
Reactome.org link: R-HSA-193706