Reaction: Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one
Cholest-5-ene-3beta,7alpha,24(S)-triol and NAD+ react to form 4-cholesten-7alpha,24(S)-diol-3-one and NADH + H+, catalyzed by HSD3B7 (3 beta-hydroxysteroid dehydrogenase type 7) in the endoplasmic reticulum membrane. Its function in vivo has been confirmed in studies of patients with defects in bile acid synthesis (Schwarz et al. 2000).
Reaction - small molecule participants:
4CHOL7a,24(S)DONE [endoplasmic reticulum membrane]
H+ [cytosol]
NADH [cytosol]
CHOL7a,24(S)DIOL [endoplasmic reticulum membrane]
NAD+ [cytosol]
Reactome.org reaction link: R-HSA-193789
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Reaction input - small molecules:
(24S)-7alpha,24-dihydroxycholesterol
NAD(1-)
Reaction output - small molecules:
(24S)-7alpha,24-dihydroxycholest-4-en-3-one
hydron
NADH(2-)
Reactome.org link: R-HSA-193789