Reaction: CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol
5β-cholestan-3α,7α,24(S)-triol, NADPH + H+, and O2 react to form 5β-cholestan-3α,7α,24(S),27-tetrol, NADP+, and H2O. This reaction occurs in the mitochondrial matrix, catalyzed by CYP27A1.
Reaction - small molecule participants:
5bCHOL3a,7a,24(s),27-tetrol [mitochondrial matrix]
NADP+ [mitochondrial matrix]
H2O [mitochondrial matrix]
O2 [mitochondrial matrix]
5β-CHOL3α,7α,24(s)-triol [mitochondrial matrix]
H+ [mitochondrial matrix]
NADPH [mitochondrial matrix]
Reactome.org reaction link: R-HSA-193792
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Reaction input - small molecules:
dioxygen
(24S)-5beta-cholestane-3alpha,7alpha,24-triol
hydron
NADPH
Reaction output - small molecules:
(24S)-5beta-cholestane-3alpha,7alpha,24,26-tetrol
NADP(+)
water
Reactome.org link: R-HSA-193792