Reaction: Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone
- in pathway: Glucocorticoid biosynthesis
Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone. This reaction is catalyzed by the isomerase activity of 3 beta-HSD, associated with the endoplasmic reticulum membrane. The active form of the enzyme is a homodimer. The enzyme occurs in two isoforms that are similar in their biochemical properties but differ in their tissue expression: type I (HSD3B1) is found in placenta and skin, while type II (HSD3B2) is found in the adrenal glands and gonads.
Reaction - small molecule participants:
17aHPROG [cytosol]
pregn-5-ene-3,20-dione-17-ol [cytosol]
Reactome.org reaction link: R-HSA-193961
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Reaction input - small molecules:
17alpha-hydroxypregn-5-ene-3,20-dione
Reaction output - small molecules:
17alpha-hydroxyprogesterone
Reactome.org link: R-HSA-193961