Reaction: CYP11B2 18-hydroxylates CORST to 18HCORST
- in pathway: Mineralocorticoid biosynthesis
Corticosterone, NADPH + H+, and O2 react to form 18-hydroxycorticosterone, NADP+, and H2O. This reaction is catalyzed by CYP11B2 associated with the inner mitochondrial membrane.
Reaction - small molecule participants:
18HCORST [mitochondrial matrix]
NADP+ [mitochondrial matrix]
H2O [mitochondrial matrix]
O2 [mitochondrial matrix]
H+ [mitochondrial matrix]
CORST [mitochondrial matrix]
NADPH [mitochondrial matrix]
18HCORST [mitochondrial matrix]
NADP+ [mitochondrial matrix]
H2O [mitochondrial matrix]
O2 [mitochondrial matrix]
H+ [mitochondrial matrix]
CORST [mitochondrial matrix]
NADPH [mitochondrial matrix]
Reactome.org reaction link: R-HSA-193995
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Reaction input - small molecules:
dioxygen
hydron
corticosterone
NADPH
dioxygen
hydron
corticosterone
NADPH
Reaction output - small molecules:
18-hydroxycorticosterone
NADP(+)
water
18-hydroxycorticosterone
NADP(+)
water
Reactome.org link: R-HSA-193995