Reaction: Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol
- in pathway: Cholesterol biosynthesis via desmosterol
Isomerization of zymosterol to cholesta-7,24-dien-3beta-ol is catalyzed by EBP in the endoplasmic reticulum. The biochemical details of the reaction have been established through studies of purified rat EBP; the role of the human enzyme has been established through studies of patients deficient in it (Derry et al. 1999; Braverman et al. 1999).
Reaction - small molecule participants:
CHdOL [endoplasmic reticulum membrane]
ZYMOL [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-195690
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Reaction input - small molecules:
zymosterol
Reaction output - small molecules:
5alpha-cholesta-7,24-dien-3beta-ol
Reactome.org link: R-HSA-195690