Reaction: 2xPPCS ligates PPanK with Cys
- in pathway: Coenzyme A biosynthesis
The conjugation of cysteine (Cys) and 4'- phosphopantothenate (PPanK) to form 4-phosphopantothenoylcysteine (PPC) , coupled to the conversion of ATP to AMP and pyrophosphate, is catalyzed by cytosolic phosphopantothenate-cysteine ligase (PPCS aka Phosphopantothenoylcysteine synthase or PPC synthase). Mammalian PPCS prefers ATP to CTP, unlike the E. coli ortholog (Daughtery et al. 2002; Manoj et al. 2003).
Reaction - small molecule participants:
PPi [cytosol]
H+ [cytosol]
PPC [cytosol]
AMP [cytosol]
L-Cys [cytosol]
ATP [cytosol]
PPanK [cytosol]
Reactome.org reaction link: R-HSA-196753
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Reaction input - small molecules:
L-cysteine zwitterion
ATP(4-)
(R)-4'-phosphonatopantothenate(3-)
Reaction output - small molecules:
diphosphate(3-)
hydron
N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-196753