Reaction: 3xPPCDC:3FMN decarboxylates PPC
- in pathway: Coenzyme A biosynthesis
The decarboxylation of phosphopantothenoylcysteine (PPC) to 4'-phosphopantetheine (PPANT) is carried out by phosphopantothenoylcysteine decarboxylase (PPCDC) (Daugherty et al. 2002). PPCDC is cytosolic and exists as a homotrimer, binding one FMN cofactor per subunit (Strauss et al. 2004). While a second isoform has been inferred from large-scale sequnceing studies, it lacks the protein's FMN-binding domain and would thus appear to be nonfunctional if it is expressed.
Reaction - small molecule participants:
PPANT [cytosol]
CO2 [cytosol]
H+ [cytosol]
PPC [cytosol]
Reactome.org reaction link: R-HSA-196840
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Reaction input - small molecules:
hydron
N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
Reaction output - small molecules:
D-pantetheine 4'-phosphate(2-)
carbon dioxide
Reactome.org link: R-HSA-196840