Reaction: NAPRT1 dimer transfers PRIB to NCA to form NAMN
- in pathway: Nicotinamide salvaging
Cytosolic nicotinate phosphoribosyltransferase (NaPRT) catalyzes the Mg++-dependent reaction of nicotinate and phosphoribosyl pyrophosphate to form nicotinate mononucleotide (NaMN, nicotinate D-ribonucleotide) and pyrophosphate. The active form of the enzyme is a homodimer (Preiss and Handler 1958; Niedel and Dietrich 1973; Hara et al. 2007).
Reaction - small molecule participants:
PPi [cytosol]
NAMN [cytosol]
PRPP [cytosol]
NCA [cytosol]
H+ [cytosol]
Reactome.org reaction link: R-HSA-197186
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Reaction input - small molecules:
5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
nicotinic acid
hydron
Reaction output - small molecules:
diphosphate(3-)
nicotinic acid D-ribonucleotide
Reactome.org link: R-HSA-197186