Reaction: NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+
- in pathway: Nicotinate metabolism
Cytosolic NAD+ kinase (NADK) catalyses the transfer of a phosphate group from ATP to NAD+, forming NADP+. This is the only way to generate NADP+ in all living organisms. NADK is tetrameric and requires one divalent metal such as Zn2+ per subunit to function correctly (Lerner et al. 2004).
Reaction - small molecule participants:
ADP [cytosol]
NADP+ [cytosol]
ATP [cytosol]
NAD+ [cytosol]
Reactome.org reaction link: R-HSA-197198
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Reaction input - small molecules:
ATP(4-)
NAD(1-)
Reaction output - small molecules:
ADP(3-)
NADP(3-)
Reactome.org link: R-HSA-197198