Reaction: QPRT transfers PRIB to QUIN to form NAMN
- in pathway: Nicotinate metabolism
The enzyme, nicotinate nucleotide pyrophosphorylase, is specific for quinolinate. Its activity is strictly dependent on Mg2+ ions being present. A phosphoribosyl group is transferred to quinolinate to form nicotinate D-ribonucleotide. This reaction represents another rate-limiting step of the pathway from tryptophan to NAD+.
Reaction - small molecule participants:
PPi [cytosol]
CO2 [cytosol]
NAMN [cytosol]
PRPP [cytosol]
H+ [cytosol]
QUIN [cytosol]
Reactome.org reaction link: R-HSA-197268
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Reaction input - small molecules:
5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
hydron
quinolinate(2-)
Reaction output - small molecules:
diphosphate(3-)
carbon dioxide
nicotinic acid D-ribonucleotide
Reactome.org link: R-HSA-197268