Reaction: MDH1 oxidizes MAL to OA
- in pathway: Gluconeogenesis
Cytosolic MDH1 (malate dehydrogenase 1) catalyzes the reaction of malate (MAL) and NAD+ to form oxaloacetate (OA) and NADH + H+ (Friedrich et al. 1988; Lo et al. 2005). The dimeric structure of the human dehydrogenase is inferred from that established for its well-studied pig homolog (Birktoft et al. 1989).
Reaction - small molecule participants:
H+ [cytosol]
OA [cytosol]
NADH [cytosol]
MAL [cytosol]
NAD+ [cytosol]
Reactome.org reaction link: R-HSA-198508
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Reaction input - small molecules:
(S)-malate(2-)
NAD(1-)
Reaction output - small molecules:
hydron
oxaloacetate(2-)
NADH(2-)
Reactome.org link: R-HSA-198508