Reaction: SLC7A4 exchanges G6P for Pi across the ER membrane
- in pathway: Gluconeogenesis
The SLC37A4 transport protein in the endoplasmic reticulum membrane mediates the exchange of cytosolic G6P (glucose-6-phosphate) and Pi (orthophosphate) from the endoplasmic reticulum lumen. Defects in this transporter are associated with glycogen storage disease type Ib (Gerin et al. 1997; Chen et al. 2008; Veiga-da-Cunha et al. 1998).
Reaction - small molecule participants:
Pi [cytosol]
G6P [endoplasmic reticulum lumen]
Pi [endoplasmic reticulum lumen]
G6P [cytosol]
Reactome.org reaction link: R-HSA-198513
======
Reaction input - small molecules:
hydrogenphosphate
alpha-D-glucose 6-phosphate(2-)
Reaction output - small molecules:
hydrogenphosphate
alpha-D-glucose 6-phosphate(2-)
Reactome.org link: R-HSA-198513