Reaction: AKT phosphorylates p21Cip1 and p27Kip1
- in pathway: Cyclin E associated events during G1/S transition
Phosphorylation of p27Kip1 at T157 and of p21Cip1 at T145 by AKT leads to their retention in the cytoplasm, segregating these cyclin-dependent kinase (CDK) inhibitors from cyclin-CDK complexes.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
ADP [cytosol]
ATP [cytosol]
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-198613
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Reaction input - small molecules:
ATP(4-)
ATP(4-)
ATP(4-)
Reaction output - small molecules:
ADP(3-)
ADP(3-)
ADP(3-)
Reactome.org link: R-HSA-198613