Reaction: CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme
- in pathway: Vitamin C (ascorbate) metabolism
Cytochrome b5 reductase (CYB5R3) catalyzes the reduction of cytosolic ferric CYB5A (CYB5A:ferriheme) to ferrous CYPB5A (CYB5A:heme), coupled to the conversion of NADH to NAD+ (Shirabe et al. 1995). CYB5R3 is associated with the outer mitochondrial membrane via a myristoyl group added post-translationally to glycine residue 2 of the protein (Borgese et al. 1993).
Reaction - small molecule participants:
NAD+ [cytosol]
H+ [cytosol]
NADH [cytosol]
Reactome.org reaction link: R-HSA-198824
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Reaction input - small molecules:
hydron
NADH(2-)
Reaction output - small molecules:
NAD(1-)
Reactome.org link: R-HSA-198824