Reaction: CYB5A:heme reduces Asc.- to AscH-
- in pathway: Vitamin C (ascorbate) metabolism
The reduction of cytosolic semidehydroascorbate (SDA) to ascorbate (AscH-) is catalyzed by cytochrome B5 (CYB5A) associated with the mitochondrial outer membrane. In the course of the reaction, the heme iron of the cytochrome is oxidized (Linster & Van Schaftingen 2007, Shirabe et al. 1995).
Reaction - small molecule participants:
AscH- [cytosol]
Asc.- [cytosol]
Reactome.org reaction link: R-HSA-198845
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Reaction input - small molecules:
monodehydro-L-ascorbate(1-)
Reaction output - small molecules:
L-ascorbate
Reactome.org link: R-HSA-198845