Reaction: Phosphopantetheine conjugation of the ACP domain of FAS
- in pathway: Vitamin B5 (pantothenate) metabolism
Cytosolic AASDHPPT (alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase) catalyzes the transfer of a phosphopantetheine moiety from coenzyme A to serine 2156 within the ACP domain of FAS (fatty acyl synthase). Only a single human enzyme with phosphopantetheinyl transferase activity has been identified, and its broad substrate specificity suggests that it may be responsible as well for the postranslational modification of enzymes of lysine catabolism (Joshi et al. 2003; Praphanphoj et al. 2001).
Reaction - small molecule participants:
PAP [cytosol]
CoA-SH [cytosol]
Reactome.org reaction link: R-HSA-199202
======
Reaction input - small molecules:
coenzyme A(4-)
Reaction output - small molecules:
adenosine 3',5'-bismonophosphate(4-)
Reactome.org link: R-HSA-199202