Reaction: creatine + ATP => phosphocreatine + ADP [CKB,CKM]
- in pathway: Creatine metabolism
Cytosolic creatine kinase catalyzes the reaction of creatine and ATP to form phosphocreatine and ADP. The active form of the enzyme is a dimer. Monomers of the cytosolic enzyme occur in two isoforms, B and M, so called because of their abundance in brain and muscle respectively. The enzyme is widely expressed in the body and many tissues express both isoforms. Both homo- (BB, MM) and heterodimers (BM) are catalytically active.
Reaction - small molecule participants:
Pcr [cytosol]
ADP [cytosol]
CRET [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-200318
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Reaction input - small molecules:
creatine zwitterion
ATP(4-)
Reaction output - small molecules:
N-phosphocreatinate(2-)
ADP(3-)
Reactome.org link: R-HSA-200318