Reaction: Creatine transport across the plasma membrane
- in pathway: Creatine metabolism
The SLC6A8 transport protein associated with the plasma membrane mediates the uptake of extracellular creatine and a sodium ion (Sora et al. 1994). Molecular and biochemical studies of patients deficient in SLC6A8 protein confirm this function in vivo (e.g., Salomons et al. 2003).
Reaction - small molecule participants:
CRET [cytosol]
Na+ [cytosol]
CRET [extracellular region]
Na+ [extracellular region]
Reactome.org reaction link: R-HSA-200396
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Reaction input - small molecules:
creatine zwitterion
sodium(1+)
Reaction output - small molecules:
creatine zwitterion
sodium(1+)
Reactome.org link: R-HSA-200396