Reaction: pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis
- in pathway: Carnitine metabolism
Acetyl-CoA carboxylase 2 (ACACB, ACC2) is involved in the regulation of mitochondrial fatty acid oxidation through the inhibition of carnitine palmitoyltransferase 1 by its product malonyl-CoA. Phosphorylated AMPK inactivates ACACB in muscle cells by phosphorylation. This results in decreased levels of malonyl CoA, contributing to the homeostasis of mitochondrial beta oxidation (Ruderman & Prentki 2004).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-200423
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-200423