Reaction: NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD
- in pathway: Nicotinate metabolism
NMNAT3 catalyzes the reaction of nicotinate D-ribonucleotide and ATP to form deamino-NAD+ (nicotinate adenine dinucleotide) and pyrophosphate (Sorci et al. 2007). The active form of the enzyme is a tetramer in vitro (Zhang et al. 2003). Recombinant FLAG-tagged protein expressed in HeLa cells localizes both to the cytosol and to mitochondria (Berger et al. 2005). The cytosolic protein is annotated here.
Reaction - small molecule participants:
PPi [mitochondrial matrix]
NAAD [mitochondrial matrix]
NAMN [mitochondrial matrix]
ATP [mitochondrial matrix]
Reactome.org reaction link: R-HSA-200474
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Reaction input - small molecules:
nicotinic acid D-ribonucleotide
ATP(4-)
Reaction output - small molecules:
diphosphate(3-)
deamido-NAD(+)
Reactome.org link: R-HSA-200474