Reaction: NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD
- in pathway: Nicotinate metabolism
NMNAT1 catalyzes the reaction of nicotinate D-ribonucleotide and ATP to form deamino-NAD+ (nicotinate adenine dinucleotide) and pyrophosphate (Schweiger et al. 2001). The active form of the enzyme in vitro is a hexamer (Zhou et al. 2002), and its activity is substantially greater in the presence of Zn++ than of Mg++ (Sorci et al. 2007). The predicted amino acid sequence of the enzyme contains a nuclear localization domain and the protein is observed to localize to the nucleus (Schweiger et al. 2001; Berger et al. 2005).
Reaction - small molecule participants:
PPi [nucleoplasm]
NAAD [nucleoplasm]
NAMN [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-200512
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Reaction input - small molecules:
nicotinic acid D-ribonucleotide
ATP(4-)
Reaction output - small molecules:
diphosphate(3-)
deamido-NAD(+)
Reactome.org link: R-HSA-200512