Reaction: MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG
- in pathway: Metabolism of folate and pterines
The formate-tetrahydrofolate ligase activity of the trifunctional MTHFD1 enzyme catalyzes the reaction of THF polyglutamate, formate, and ATP to form 10-formylTHF polyglutamate, ADP, and orthophosphate. MTHFD1 is cytosolic and occurs as a dimer. The human enzyme has been identified and partially characterized biochemically (Hum et al. 1988); additional reaction details can be inferred from the properties of the well-studied homologous rabbit enzyme (Villar et al. 1985).
Reaction - small molecule participants:
Pi [cytosol]
ADP [cytosol]
10-formyl-THFPG [cytosol]
ATP [cytosol]
HCOOH [cytosol]
THFPG [cytosol]
Reactome.org reaction link: R-HSA-200711
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Reaction input - small molecules:
ATP(4-)
formate
tetrahydrofolyl-poly(glutamic acid) macromolecule
Reaction output - small molecules:
hydrogenphosphate
ADP(3-)
10-formyltetrahydrofolyl polyglutamate macromolecule
Reactome.org link: R-HSA-200711