Reaction: ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA
- in pathway: Synthesis of very long-chain fatty acyl-CoAs
Membrane-associated acyl-CoA synthetase long-chain family members 1,3,5 and 6 (ACSL1,3,5,6) catalyse the conjugation of palmitate (PALM) with CoA to form palmitoyl-CoA (PALM-CoA). Human ACSL1 has not been characterized in detail, but available data suggest that it is associated specifically with the membrane of the endoplasmic reticulum and that it can act on oleic acid as well as on palmitic acid (Malhotra et al. 1999, Fujimoto et al. 2007, Gassler et al. 2007).
Reaction - small molecule participants:
PPi [cytosol]
H2O [cytosol]
PALM-CoA [cytosol]
AMP [cytosol]
ATP [cytosol]
PALM [cytosol]
CoA-SH [cytosol]
Reactome.org reaction link: R-HSA-201035
======
Reaction input - small molecules:
ATP(4-)
hexadecanoic acid
coenzyme A(4-)
Reaction output - small molecules:
diphosphate(3-)
water
palmitoyl-CoA(4-)
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-201035