Reaction: MME:Zn2+ hydrolyses AGT(34-42)
- in pathway: Metabolism of Angiotensinogen to Angiotensins
Neprilysin (MME aka neutral endopeptidase NEP) hydrolyzes angiotensin-(1-9) (AGT(34-42)) to yield angiotensin-(1-7) (Rice et al. 2004). The hydrolysis of angiotensin-(1-9) catalyzed by neprilysin is more efficient than that catalyzed by angiotensin-converting enzyme (ACE) (Rice et al. 2004). MME is the major enzyme involved in the metabolic inactivation of a number of bioactive signaling peptides including the enkephalins, substance P, endothelin, bradykinin, atrial natriuretic factor, and the incretin hormone glucagon-like peptide 1. MME requires zinc as cofactor (Oefner et al. 2004, Oefner et al. 2007).
Reaction - small molecule participants:
H2O [extracellular region]
Reactome.org reaction link: R-HSA-2022368
======
Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-2022368