Reaction: ANPEP hydrolyzes Angiotensin-(2-8) to Angiotensin-(3-8)
- in pathway: Metabolism of Angiotensinogen to Angiotensins
Aminopeptidase N (APN, ANPEP, aminopeptidase M, alanyl aminopeptidase) hydrolyzes angiotensin-(2-8) (angiotensin III) to yield angiotensin-(3-8) (angiotensin IV) (see the positive control reactions in Diaz-Perales et al. 2005). Aminopeptidase O (AOPEP) also hydrolyzes angiotensin-(2-8) to angiotensin-(3-8) in vitro (Diaz-Perales et al. 2005) but AOPEP is located in the nucleolus in vivo (Axton et al. 2008) and angiotensin-(2-8) has not been observed in the nucleus.
Reaction - small molecule participants:
H2O [extracellular region]
Reactome.org reaction link: R-HSA-2022393
======
Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-2022393