Reaction: ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8)
- in pathway: Metabolism of Angiotensinogen to Angiotensins
Aminopeptidase A (APA, ENPEP) hydrolyzes the N-terminal amino acid of angiotensin-(1-8) (angiotensin II) to yield angiotensin-(2-8) (angiotensin III) (Goto et al. 2006). The catalysis is more specific and efficient in the presence of calcium ions (Goto et al. 2006).
Reaction - small molecule participants:
H2O [extracellular region]
Reactome.org reaction link: R-HSA-2022399
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-2022399