Reaction: Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)
- in pathway: Metabolism of Angiotensinogen to Angiotensins
Renin bound to the (pro)renin receptor (ATP6AP2) hydrolyzes angiotensinogen to yield angiotensin-(1-10) (angiotensin I) (Nguyen et al. 2002). Binding to the (pro)renin receptor increases the catalytic efficiency of renin 4-fold (Nguyen et al. 2002). Aliskiren, a drug used clinically to treat hypertension, inhibits cleavage of angiotensinogen by renin (Gossas et al. 2011, Wood et al. 2003, reviewed in Gerc et al. 2009).
Reaction - small molecule participants:
H2O [extracellular region]
Reactome.org reaction link: R-HSA-2022403
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-2022403