Reaction: Phosphorylation of PLC-gamma1
- in pathway: Generation of second messenger molecules
Three tyrosine residues at positions 771, 783 and 1254 in PLC-gamma1 have been identified as the sites of receptor tyrosine kinase phosphorylation. Of these Y783 and Y1254 are required for activation of PLC-gamma1. The phosphorylation of the tyrosine residues and the activation of PLC-gamma1 is mediated by both Syk tyrosine kinase ZAP-70 and Tec kinase ITK.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-202248
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Reaction input - small molecules:
ATP(4-)
ATP(4-)
Reaction output - small molecules:
ADP(3-)
ADP(3-)
Reactome.org link: R-HSA-202248