Reaction: NDST1-4 N-deacetylates GlcNAc residues in heparan
- in pathway: HS-GAG biosynthesis
The bifunctional enzymes heparan sulfate N-deacetylase/N-sulfotransferase 1-4 (NDST1-4) catalyse both the N-deacetylation and the N-sulfation of N-acetylglucosamine (GlcNAc) of heparan (Dixon et al. 1995, Duncan et al. 2006, Aikawa & Esko 1999, Aikawa et al. 2001). The N-deacetylation of a GlcNAc residue to a glucosamine residue is shown here.
Reaction - small molecule participants:
CH3COO- [Golgi lumen]
H2O [Golgi lumen]
Reactome.org reaction link: R-HSA-2022887
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Reaction input - small molecules:
water
Reaction output - small molecules:
acetic acid
Reactome.org link: R-HSA-2022887