Reaction: Phosphorylation of CARMA1
- in pathway: Downstream TCR signaling
Antigen receptor triggered PKC theta dependent linker phosphorylation of S559 residue is required to release this inhibition and expose the CARD motif for downstream Bcl10 recruitment (Sommer et al. 2005). PDK1 and maybe other unknown adapter proteins bring PKC theta and CARMA1 into close proximity, facilitating PKC theta mediated CARMA1 phosphorylation and consequent activation.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-202437
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-202437