Reaction: B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG
- in pathway: Keratan sulfate biosynthesis
The UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase family (B3GNTs) consists of 9 members in humans (Kolbinger et al, 1998; Shiraishi et al, 2001; Togayachi et al, 2001; Iwai et al, 2002; Huang et al, 2004; Ishida et al, 2005; Zheng et al, 2004). Members 1,2,3,4 and 7 can catalyse the addition of N-acetylglucosamine (GlcNAc) to the galactosyl residue of the sachharide chain in a beta-1,3 linkage to form a structure called Keratan-proteoglycan (PG).
Reaction - small molecule participants:
UDP [Golgi lumen]
UDP-GlcNAc [Golgi lumen]
Reactome.org reaction link: R-HSA-2025724
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Reaction input - small molecules:
UDP-N-acetyl-alpha-D-glucosamine(2-)
Reaction output - small molecules:
UDP(3-)
Reactome.org link: R-HSA-2025724