Reaction: PIP3 binds to RhoA and activates it
- in pathway: PI3K/AKT activation
Several guanine exchange factors (GEFs) for the Rho family of GTPases contain PH domains that bind to PIP3. RhoA protein activation is a mechanism whereby PI3K acts independently of AKT (Chong et al. 1994, Oude Weernink et al. 1997).
Reaction - small molecule participants:
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Reactome.org reaction link: R-HSA-202692
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Reaction input - small molecules:
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
Reaction output - small molecules:
Reactome.org link: R-HSA-202692