Reaction: Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N
- in pathway: Signaling by Hippo
Cytosolic LATS1 and LATS2 are phosphorylated by phospho-STK3 (MST2)/N (Lee et al. 2001). LATS proteins are known to form complexes with MOB1 proteins and this reaction is annotated with LATS:MOB1 complexes as its substrate. Serine-909 and threonine-1079 have been identified as LATS1 residues phosphorylated by STK4 (MST1) kinase; STK3(MST2)/N is inferred to act similarly. The target residues of LATS2 have not been identified experimentally but are inferred to be serine-872 and threonine-1041 based on sequence similarity.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-2028673
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-2028673