Reaction: Phosphorylation and activation of PLCG
- in pathway: Role of phospholipids in phagocytosis
PLCG is tyrosine phosphorylated by either SYK or Src kinases on three tyrosine residues and this phosphorylation enhances the activity of PLCG. Although maximal activation requires binding of PLCG to PIP3 with its plecstrin homology (PH) domain.
Reaction - small molecule participants:
ADP [cytosol]
PI(3,4,5)P3 [plasma membrane]
ATP [cytosol]
Reactome.org reaction link: R-HSA-2029268
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Reaction input - small molecules:
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-2029268