Reaction: depalmitoylation of eNOS
- in pathway: eNOS activation
Increases in intracellular calcium and calmodulin stimulate depalmitoylation of eNOS by acyl protein thioesterase 1, which displaces eNOS from the membrane. This might be a mechanism to downregulate NO production following intense stimuli.
Reaction - small molecule participants:
PALM [early endosome]
Reactome.org reaction link: R-HSA-203613
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Reaction input - small molecules:
Reaction output - small molecules:
hexadecanoic acid
Reactome.org link: R-HSA-203613