Reaction: PDK isoforms phosphorylate lipo-PDH
- in pathway: Regulation of pyruvate dehydrogenase (PDH) complex
In the nucleus, cellular retinoic acid-binding protein 1 or 2 (CRABP1 or 2), bound to all-trans-retinoic acid (atRA), directly binds to the heterodimeric complex of retinoic acid receptor alpha RXRA) and peroxisome proliferator-activated receptor delta (PPARD). When bound to PPARD, atRA can significantly increase the expression of proteins involved in energy metabolism such as PDK via induction of PPARD (Wolf 2010).
Reaction - small molecule participants:
ADP [mitochondrial matrix]
ATP [mitochondrial matrix]
ADP [mitochondrial matrix]
ATP [mitochondrial matrix]
ADP [mitochondrial matrix]
ATP [mitochondrial matrix]
ADP [mitochondrial matrix]
ATP [mitochondrial matrix]
Reactome.org reaction link: R-HSA-203946
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Reaction input - small molecules:
ATP(4-)
ATP(4-)
ATP(4-)
ATP(4-)
Reaction output - small molecules:
ADP(3-)
ADP(3-)
ADP(3-)
ADP(3-)
Reactome.org link: R-HSA-203946