Reaction: Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA
- in pathway: alpha-linolenic acid (ALA) metabolism
Alpha-linoloyl-CoA is converted to Stearidonoyl-CoA (SDA, 6,9,12,15-18:3(n-3)) by delta-6-destaurase (fatty acid desaturase-2, FADS2). FADS2 uses the cytochrome b5 system to add a double bond at position 6. This is the rate limiting step in alpha-linolenic acid (ALA) metabolism (Horrobin 1993).
Reaction - small molecule participants:
NAD+ [endoplasmic reticulum lumen]
H2O [endoplasmic reticulum lumen]
SDA-CoA [endoplasmic reticulum lumen]
O2 [endoplasmic reticulum lumen]
NADH [endoplasmic reticulum lumen]
ALA-CoA [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-2046084
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Reaction input - small molecules:
dioxygen
NADH(2-)
alpha-linolenoyl-CoA
Reaction output - small molecules:
NAD(1-)
water
(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA
Reactome.org link: R-HSA-2046084