Reaction: Translocation of tetracosahexaenoyl-CoA to peroxisomes
- in pathway: alpha-linolenic acid (ALA) metabolism
The 24-carbon tetracosahexaenoyl-CoA (6,9,12,15,18,21-24:6(n-3) is transported to peroxisomes to undergo a putative single cycle of peroxisomal beta-oxidation, producing Docosahexaenoic Acid (DHA) (Sprecher 2002, Luthria et al. 1996).
Reaction - small molecule participants:
PI [endoplasmic reticulum membrane]
ADP [endoplasmic reticulum membrane]
THA-CoA [peroxisomal matrix]
THA-CoA [endoplasmic reticulum lumen]
ATP [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-2046087
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Reaction input - small molecules:
(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA
ATP(4-)
Reaction output - small molecules:
1-phosphatidyl-1D-myo-inositol(1-)
ADP(3-)
(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA
Reactome.org link: R-HSA-2046087