Reaction: Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA
- in pathway: Linoleic acid (LA) metabolism
DGL-CoA (8,11,14-eicosatrienoyl-CoA) undergoes desaturation by delta 5-desaturase (D5-desaturase) forming arachidonoyl-CoA (AA-CoA, 5,8,11,14-Eicosatetraenoic acid). D5-desaturase has 62% sequence identity with D6-desaturase but desaturates a different carbon atom, adding a double bond at position C5 in arachidonoyl-CoA (AA-CoA). AA can be metabolized by variety of oxygenases (including cyclo-oxygenase and lipoxygenase systems) to form a family of varying products known as eicosanoids, prostaglandins, leukotrines and thromboxanes thus playing important role in inflamation response.
Reaction - small molecule participants:
NAD+ [endoplasmic reticulum lumen]
H2O [endoplasmic reticulum lumen]
AA-CoA [endoplasmic reticulum lumen]
O2 [endoplasmic reticulum lumen]
NADH [endoplasmic reticulum lumen]
DGL-CoA [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-2046092
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Reaction input - small molecules:
dioxygen
NADH(2-)
all-cis-icosa-8,11,14-trienoyl-CoA
Reaction output - small molecules:
NAD(1-)
water
arachidonoyl-CoA(4-)
Reactome.org link: R-HSA-2046092