Reaction: Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA
- in pathway: Linoleic acid (LA) metabolism
The first major step in the metabolism of linoleic acid (LA) is desaturation of delta 9,12-octadecadienoyl CoA/linoleoyl CoA (LA-CoA) to delta 6,9,12-octodecatrienoyl CoA/gamma-lenoleoyl CoA (GLA-CoA). This step is catalyzed by delta-6-destaurase (fatty acid desaturase-2, FADS2) which introduces a cis-double bond between carbons 6 and 7. This is the rate limiting step in LA metabolism (Horrobin 1993).
Reaction - small molecule participants:
NAD+ [endoplasmic reticulum lumen]
H2O [endoplasmic reticulum lumen]
GLA-CoA [endoplasmic reticulum lumen]
O2 [endoplasmic reticulum lumen]
NADH [endoplasmic reticulum lumen]
LA-CoA [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-2046096
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Reaction input - small molecules:
dioxygen
NADH(2-)
linoleoyl-CoA
Reaction output - small molecules:
NAD(1-)
water
gamma-linolenoyl-CoA
Reactome.org link: R-HSA-2046096