Reaction: Desaturation of tetracosapentaenoyl-CoA to tetracosahexaenoyl-CoA
- in pathway: alpha-linolenic acid (ALA) metabolism
Tetracosapentaenoyl-CoA (9,12,15,18,21-24:5(n-3)) is further converted by delta 6-desaturase (FADS2) to tetracosahexaenoyl-CoA (6,9,12,15,18,21-24:6(n-3)).
Reaction - small molecule participants:
NAD+ [endoplasmic reticulum lumen]
H2O [endoplasmic reticulum lumen]
THA-CoA [endoplasmic reticulum lumen]
O2 [endoplasmic reticulum lumen]
TPA-CoA [endoplasmic reticulum lumen]
NADH [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-2046099
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Reaction input - small molecules:
dioxygen
(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA
NADH(2-)
Reaction output - small molecules:
NAD(1-)
water
(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA
Reactome.org link: R-HSA-2046099