Reaction: DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A
- in pathway: Hypusine synthesis from eIF5A-lysine
Cytosolic deoxyhypusine synthase (DHPS) tetramer catalyzes the reaction of the deoxyhypusine (Dhp) residue in EIF5A protein (Dhp-K50-EIF5A) with 1,3 diaminopropane, NADH and H+ to form EIF5A, spermidine (SPM), and NAD+ (Park et al. 2003; Park 2006). While this reaction is readily observed in vitro, it is probably minimized by the rapid, irreversible conversion of EIF5A Dhp residues to hypusine.
Reaction - small molecule participants:
SPM [cytosol]
NAD+ [cytosol]
H+ [cytosol]
1,3-diaminopropane [cytosol]
NADH [cytosol]
Reactome.org reaction link: R-HSA-204617
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Reaction input - small molecules:
hydron
trimethylenediamine
NADH(2-)
Reaction output - small molecules:
spermidine(3+)
NAD(1-)
Reactome.org link: R-HSA-204617